Claire Augustus was the first noted transgender Character in the web comic.
Due to the format of the web comic, multiple simultaneous plot lines, the full details of Claire's transition have not been detailed currently; This has caused much consternation among the fan-base, being Claire is currently in a sexual relationship with the starting character in the web-comic, Marten Reed.
Being the web-comic has a multiple plot lines format, the full details of Claire's transition have not been reveled. Claire told Marten early in the comic that Claire is a transsexual that she identified as female and had started transitioning to female when she was a college freshman. In the comic Clare stated she was 24yr.
A major fan-base issue is Claire has been shown to be very apprehensive to even minor medical procedures, there was a plot of her deciding to get her ears pierced and having to have Marten go with her for moral support.
Theses point to maybe Clair had not physically transitioned to Female while Clair and Marten began the sexual portion of their relationship. This is calling into question of the Heterosexual status of Marten Reed.
This is causing issues between the fan-base between the fans and wiki-admins that are supportive to non-heterosexual orientations, and other fans that feel upset about theses facts.
Because of changes to the Wiki entries for Claire's gender and Marten's sexual orientation there are been changes to the admin edit guidelines for this Wiki. This has lead to edit issues on this Wiki and the locking of the main articles for Claire and Martin. Also on the Wiki there have been anonymous changes and entries disparaging the web-comic creator, Jeph Jacques. These also upset the fan-base, even if most of the updates are humorous at first, but they are reverted back shortly after the edit.